Estimation of Population Parameters and Recombination Rates From Single Nucleotide Polymorphisms
نویسندگان
چکیده
منابع مشابه
Estimation of population parameters and recombination rates from single nucleotide polymorphisms.
Some general likelihood and Bayesian methods for analyzing single nucleotide polymorphisms (SNPs) are presented. First, an efficient method for estimating demographic parameters from SNPs in linkage equilibrium is derived. The method is applied in the estimation of growth rates of a human population based on 37 SNP loci. It is demonstrated how ascertainment biases, due to biased sampling of loc...
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We describe a method for co-estimating r = C/mu (where C is the per-site recombination rate and mu is the per-site neutral mutation rate) and Theta = 4N(e)mu (where N(e) is the effective population size) from a population sample of molecular data. The technique is Metropolis-Hastings sampling: we explore a large number of possible reconstructions of the recombinant genealogy, weighting accordin...
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RECENT studies employing single-sperm haplotyping ( Jeffreys and Neumann 2002), pedigrees (Visser et al. 2005), and population studies using dense genetic marker data (Crawford et al. 2004; McVean et al. 2004; Myers et al. 2005) have shown that there is a large amount of local variation in recombination rate in the human genome. Methods to estimate fine-scale recombination rates from population...
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Uncovering DNA sequence variations that correlate with phenotypic changes, e.g., diseases, is the aim of sequence variation studies. Common types sequence variations are Single nucleotide polymorphism (SNP, pronounced snip).SNPs are the third-generation molecular marker. SNP represents a DNA sequence variant of a single base pair with the minor allele occurring in more than 1% of a given popula...
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ژورنال
عنوان ژورنال: Genetics
سال: 2000
ISSN: 1943-2631
DOI: 10.1093/genetics/154.2.931